(201-OD) Intermediate Population Modeling using Phoenix NLME

36 modules



Course Length
40 hours

Tom Jones

$500 - 1000


Cost - $1,000 (Academia $500, Africa/India $250)

Course Description

This course will help you fill the gaps to become a better Population Pharmacokinetic and Pharmacodynamic (PK/PD) modeler.  This e-learning course focuses on Population PK/PD modeling and simulation using the intuitive interface of Phoenix NLME.   This course topics include: population PK analysis with covariates, covariate search methods, complex PK models including multiple absorption processes and parent-metabolite models, Emax PK/PD models, an introduction to categorical response PD models, and modeling BLQ data in Phoenix NLME. 

The concepts of each topic are explained in detail via instructional videos. Exercises are introduced and you are expected to practice concepts learned by performing the exercises on your own. Step by step solution videos are also provided to check your work. Your understanding of the concepts discussed is tested via short quizzes throughout the course.

If you are an academic user, please contact us so we can update your account profile to give you access to academic pricing.  Note that you must register with an email address that is associated with an academic institution to get academic pricing.

If you are located in India, please contact us so we can provide a coupon that will give 75% off the full price of the course.  You will need to provide proof that you are physically located in India to get the coupon.

Software Used

Phoenix NLME™

A temporary (30-day) license is provided to subscribers of this course.  When you are ready to start the practice exercises in this course, contact us to request your license.

Accessing the Course

After registering for this course, login to www.certarauniversity.com and you will see the course on your Dashboard. 

You will have access to this course for a period of 3 years after the purchase.

The purchase is for a single seat in the course. No sharing the login between different individuals is allowed. Additional seats must be purchased if more than one person wishes to take the training course.

Course Length: 

The course provides approximately 10 hours of video instruction which includes a practical component that you can do at your own pace. It is expected to take participants about 40+ hours to complete, including time to perform the tasks in Phoenix.


It is assumed that learners have familiarity with individual PK/PD modeling as well as introductory level population PK/PD modeling experience. Participants should have a good background in pharmacokinetics and pharmacodynamics, and prior experience with the Phoenix is recommended. Participants should also be able to perform the tasks in both the following Certara University courses:


Christopher Mehl

Christopher Mehl is a Senior Software Trainer with Certara University, and has been with Certara since 2003. His educational background is a BS in Molecular Biology from the Ohio State University, and an MS in Pharmacology from the University of Wisconsin. He has conducted over 200 training courses with Certara products such as Phoenix WinNonlin, IVIVC, NLME, PKS, and Trial Simulator. These include workshops at the US Food and Drug Administration, universities, customer sites, and courses open to the public.


By completing/passing this course, you will attain the certificate Certificate of Completion

Course Overview: Intermediate Population PKPD Modeling Using Phoenix NLME
{{ vm.helper.t('reports.module') }}
Lecture: Review of Basic Compartmental Models
{{ vm.helper.t('reports.module') }}
Quiz 1: Review of Compartmental Modeling
{{ vm.helper.t('reports.module') }}
Lecture: Statistical Aspects of Population Analysis (2 parts)
{{ vm.helper.t('reports.module') }}
Quiz 2: Statistical Aspects of Population Modeling
{{ vm.helper.t('reports.module') }}
Exercise 1: Pop PK Base Model (2 parts)
{{ vm.helper.t('reports.module') }}
Lecture: Covariate Modeling (3 parts)
{{ vm.helper.t('reports.module') }}
Quiz 3: Covariate Modeling
{{ vm.helper.t('reports.module') }}
Exercise 2: Covariate Modeling (5 parts)
{{ vm.helper.t('reports.module') }}
Exercise 3: PK/PD Simulation with Continuous Data
{{ vm.helper.t('reports.module') }}
Lecture: PK/PD Modeling Binary Outcomes (includes Background for Exercise 4)
{{ vm.helper.t('reports.module') }}
Quiz 4: PD Modeling of Binary Responses
{{ vm.helper.t('reports.module') }}
Exercise 4: PK/PD Modeling Binary Outcomes (4 parts)
{{ vm.helper.t('reports.module') }}
Lecture: Modeling Multinomial Categorical Responses (2 parts)
{{ vm.helper.t('reports.module') }}
Quiz 5: Multinomial Categorical Responses
{{ vm.helper.t('reports.module') }}
Exercise 5: Multinomial Categorical Response Model (6 parts)
{{ vm.helper.t('reports.module') }}
Lecture: Covariate Styles and Options
{{ vm.helper.t('reports.module') }}
Lecture: Handling Crossover Studies and Inter-Occasion Variability (IOV) in PHX NLME
{{ vm.helper.t('reports.module') }}
Quiz 6: Covariate Styles and Options
{{ vm.helper.t('reports.module') }}
Exercise 6: Handling Crossover Studies and Inter-Occasion Variability (IOV) (5 parts)
{{ vm.helper.t('reports.module') }}
Lecture: Graphical Model Basics and Setup for Exercise 7: IV/SC & Bioavailability
{{ vm.helper.t('reports.module') }}
Exercise 7: Simultaneous Fitting of IV & SC data with Bioavailability Estimation (3 parts)
{{ vm.helper.t('reports.module') }}
Exercise 8: Multiple Absorption Routes (2 parts)
{{ vm.helper.t('reports.module') }}
Exercise 9: Simultaneous Modeling of Parent Drug and Multiple Metabolites (4 parts)
{{ vm.helper.t('reports.module') }}
Quiz 7: Graphical Model Interface
{{ vm.helper.t('reports.module') }}
Lecture: Covariance Modeling and Interpreting the Omega Matrix (includes shrinkage)
{{ vm.helper.t('reports.module') }}
Quiz 8: Covariance Modeling and Interpreting the Omega Matrix
{{ vm.helper.t('reports.module') }}
Lecture: Modeling BLQ Data in Phoenix NLME
{{ vm.helper.t('reports.module') }}
Quiz 9: Modeling BLQ Data in Phoenix NLME
{{ vm.helper.t('reports.module') }}
Exercise 10: Modeling BLQ Data in Phoenix NLME (5 parts)
{{ vm.helper.t('reports.module') }}
Lecture: Visual Predictive Check (VPC) Options for Continuous Data
{{ vm.helper.t('reports.module') }}
Quiz 10: Visual Predictive Check (VPC) for Continuous Data
{{ vm.helper.t('reports.module') }}
Lecture: Ordinary Differential Equation (ODE) Solvers
{{ vm.helper.t('reports.module') }}
Lecture: NLME Run Mode Algorithms
{{ vm.helper.t('reports.module') }}
Quiz 11: Phoenix NLME Run Algorithms
{{ vm.helper.t('reports.module') }}
End of Course Feedback
{{ vm.helper.t('courses.survey') }}
Added about 2 months ago, by wafaa
Added 4 months ago, by Magali
Added 5 months ago, by Anonymous
Added 5 months ago, by MEI
Added 5 months ago, by Dana
Added 5 months ago, by Sauda
Added 8 months ago, by Rosa
Added 9 months ago, by Carol
Added over 1 year ago, by Ken
Added over 1 year ago, by Cecile
Very usefull

Note: the launching of a new Certara website makes it necessary to publish a new versions of these Terms and Conditions for Certara University.  The Certara "Privacy" link below has a new URL.  The rest of the terms are unchanged from the previous version.

User Accounts and Registrations

The email address used for your user login must be an individual account.  No sharing of user accounts between multiple individuals is allowed.  Each user account (and any associated course registrations) is for a specific person, and cannot be transferred to a different individual once the course has started.  

Course Materials

As a course registrant, you may view and read all materials related to your registered courses. However, you may not share, communicate, publish, copy or in any manner distribute to other parties the course materials, reference material provided, assignment solutions, quiz questions, exam questions, links or any other materials. 

Cancellation Policy

Classroom Courses

Certara retains the right to cancel sessions, if 30 calendar days before the first day of class, there are fewer than five students enrolled.  Participants should wait to book nonrefundable travel until they receive confirmation from Certara that a class has sufficient registrations to proceed.   

If a scheduled class is cancelled, Certara will notify enrolled students at least thirty calendar days before the first day of the scheduled class and the full cost of the course would be refunded. Certara will not be responsible for any airfare, accommodation or other costs incurred by registrants in the event a course is cancelled for any reason. If Certara cancels a course within 30 days for any unforeseen reason a full refund will be issued and airfare exchange fees may be refunded.

If you cannot attend the session for which you have enrolled, you can (1) choose a different session of the same course, (2) have another person attend in your place, or (3) you may be able to get a full or partial refund, based on the number of days prior to the session, as shown in the table.  

Notification of Cancellation by Participant Amount of Refund
1-30 Calendar Days 0% Refund
31-59 Calendar Days 50% Refund
60 Calendar Days or More 100% Refund

Live Online Courses

There are no refunds for Live Online courses.  Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.

e-Learning and Certifications

There are no refunds for e-Learning courses or certifications.  Course expiration dates can be found on your Dashboard.

Electronic Communication

We will send you email notifications regarding your training courses, including enrollment confirmations, purchase confirmations, and reminders of upcoming sessions.  We will also send email for general announcements about the site.  You can opt out of these emails if you wish (located in your profile).


Full terms and conditions applicable to this LMS are available at the Certara Legal web page.

Updated: Certara is committed to protecting your privacy.  Details of our privacy policy are available at the Privacy web page. 

Shopping Cart

Your cart is empty