(201-OD) Intermediate Population Modeling using Phoenix NLME

Content
36 modules

Difficulty
Intermediate

Rating

Course Length
40 hours

Instructor
Thomas Jones

Price
$830 - 1000

Description

Cost - $1,000 (Academia $830)

This course will help you fill the gaps to become a better Population Pharmacokinetic and Pharmacodynamic (PK/PD) modeler.  This e-learning course focuses on Population PK/PD modeling and simulation using the intuitive interface of Phoenix NLME.   This course topics include: population PK analysis with covariates, covariate search methods, complex PK models including multiple absorption processes and parent-metabolite models, Emax PK/PD models, an introduction to categorical response PD models, and modeling BLQ data in Phoenix NLME. 

The concepts of each topic are explained in detail via instructional videos. Exercises are introduced and you are expected to practice concepts learned by performing the exercises on your own. Step by step solution videos are also provided to check your work. Your understanding of the concepts discussed is tested via short quizzes throughout the course.

If you are an academic user, please contact us so we can update your account profile to give you access to academic pricing.  Note that you must register with an email address that is associated with an academic institution to get academic pricing.

Software Used

Phoenix NLME™

A temporary (30-day) license is provided to subscribers of this course.  When you are ready to start the practice exercises in this course, contact us to request your license.

Accessing the Course

After registering for this course, login to www.certarauniversity.com and you will see the course on your Dashboard. 

You will have access to this course for a period of 3 years after the purchase.

The purchase is for a single seat in the course. No sharing the login between different individuals is allowed. Additional seats must be purchased if more than one person wishes to take the training course.

Course Length: 

The course provides approximately 10 hours of video instruction which includes a practical component that you can do at your own pace. It is expected to take participants about 40+ hours to complete, including time to perform the tasks in Phoenix.

Prerequisites

It is assumed that learners have familiarity with individual PK/PD modeling as well as introductory level population PK/PD modeling experience. Participants should have a good background in pharmacokinetics and pharmacodynamics, and prior experience with the Phoenix is recommended. Participants should also be able to perform the tasks in both the following Certara University courses:

Instructor

Christopher Mehl

Christopher Mehl is a Senior Software Trainer with Certara University, and has been with Certara since 2003. His educational background is a BS in Molecular Biology from the Ohio State University, and an MS in Pharmacology from the University of Wisconsin. He has conducted over 200 training courses with Certara products such as Phoenix WinNonlin, IVIVC, NLME, PKS, and Trial Simulator. These include workshops at the US Food and Drug Administration, universities, customer sites, and courses open to the public.

Certificate

By completing/passing this course, you will attain the certificate Certificate of Completion

1
Course Overview: Intermediate Population PKPD Modeling Using Phoenix NLME
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Lecture: Review of Basic Compartmental Models
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Quiz 1: Review of Compartmental Modeling
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Lecture: Statistical Aspects of Population Analysis (2 parts)
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Quiz 2: Statistical Aspects of Population Modeling
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Exercise 1: Pop PK Base Model (2 parts)
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Lecture: Covariate Modeling (3 parts)
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Quiz 3: Covariate Modeling
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Exercise 2: Covariate Modeling (5 parts)
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Exercise 3: PK/PD Simulation with Continuous Data
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Lecture: PK/PD Modeling Binary Outcomes (includes Background for Exercise 4)
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Quiz 4: PD Modeling of Binary Responses
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Exercise 4: PK/PD Modeling Binary Outcomes (4 parts)
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Lecture: Modeling Multinomial Categorical Responses (2 parts)
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Quiz 5: Multinomial Categorical Responses
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Exercise 5: Multinomial Categorical Response Model (6 parts)
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Lecture: Covariate Styles and Options
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Lecture: Handling Crossover Studies and Inter-Occasion Variability (IOV) in PHX NLME
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Quiz 6: Covariate Styles and Options
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Exercise 6: Handling Crossover Studies and Inter-Occasion Variability (IOV) (5 parts)
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Lecture: Graphical Model Basics and Setup for Exercise 7: IV/SC & Bioavailability
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Exercise 7: Simultaneous Fitting of IV & SC data with Bioavailability Estimation (3 parts)
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Exercise 8: Multiple Absorption Routes (2 parts)
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Exercise 9: Simultaneous Modeling of Parent Drug and Multiple Metabolites (4 parts)
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Quiz 7: Graphical Model Interface
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Lecture: Covariance Modeling and Interpreting the Omega Matrix (includes shrinkage)
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Quiz 8: Covariance Modeling and Interpreting the Omega Matrix
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Lecture: Modeling BLQ Data in Phoenix NLME
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Quiz 9: Modeling BLQ Data in Phoenix NLME
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Exercise 10: Modeling BLQ Data in Phoenix NLME (5 parts)
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Lecture: Visual Predictive Check (VPC) Options for Continuous Data
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Quiz 10: Visual Predictive Check (VPC) for Continuous Data
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Lecture: Ordinary Differential Equation (ODE) Solvers
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Lecture: NLME Run Mode Algorithms
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Quiz 11: Phoenix NLME Run Algorithms
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End of Course Feedback
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