(200-OD) Intermediate PK/PD Modeling using Phoenix WinNonlin

Content
95 modules

Difficulty
Intermediate

Rating

Course Length
40 hours

Instructor
Ana Henry

Price
$900 - 1800

Description

Cost - $1800 (Academia $900)

This course focuses on PK/PD individual data analysis using PK compartmental models and PK/PD models. The intermediate PK/PD course will teach you how to set the models in Phoenix WinNonlin and how to interpret the results. The course will guide you through the process of selecting the best model and how to make predictions with the final model. Model selection is performed selecting library models, building the model graphically or coding the model in PML language.

Course topics include nonlinear modelling theory, fitting PK data, effect compartment PK/PD models, direct and indirect response PK/PD models, analyzing binary data, designing better studies and combining data among subjects. A high level overview of population methods is provided (Note that population methods are covered in detail in courses that use Phoenix NLME).

The concepts of each topic are explained in detail via instructional videos. Exercises are introduced and you are expected to practice concepts learned by performing the exercises on your own. Step by step solution videos are also provided to check your work. Your understanding of the concepts discussed is tested via short quizzes throughout the course.

If you are an academic user, please contact us so we can update your account profile to give you access to academic pricing.  Note that you must register with an email address that is associated with an academic institution to get academic pricing.

Software Used

Phoenix WinNonlin™

 A temporary (30-day) license is provided to subscribers of this course.  When you are ready to start the practice exercises in this course, contact us to request your license.

Accessing the Course

After registering for this course, login to www.certarauniversity.com and see the course under the Catalog Section ‘My Courses’. 

You will have access to this course for a period of 3 years after the purchase.

The purchase is for a single seat in the course. No sharing the login between different individuals is allowed. Additional seats must be purchased if more than one person wishes to take the training course.

Course Length: 

The course provides approximately 16 hours of video instruction which includes a practical component that you can do at your own pace. It is expected to take participants about 40+ hours to complete, including time to perform the tasks in Phoenix.

Prerequisites

It is assumed that learners have familiarity with NCA and individual PK/PD modeling, a good background in pharmacokinetics and pharmacodynamics, and prior experience with the Phoenix is recommended.

Participants should also be able to perform the tasks in the following Certara University courses:

Instructor

Ana Henry has extensive experience in a variety of roles in the Pharmaceutical industry. Most recently she acted as product manager for the complete suite of Certara Pharsight desktop products, personally leading the development of Phoenix®, the industry’s premier PK/PD software platform. Currently, she is with Certara University’s Scientific Training and Education Department, tasked with training and content development of on-demand courses. Ana has extensive experience in software demonstration and training and is adept at offering technical expertise and evaluation of software products. She has trained and provided support for Phoenix WinNonlin, Phoenix Connect, Phoenix NLME, Pharsight Knowledgebase Suite, AutoPilot, PKS Reporter, Trial Simulator, and PK/PD methodology courses. Prior to Certara, Ana worked in the pharmaceutical industry as a biostatistician and a pharmacokineticist, designing, analyzing and reporting on clinical studies. Ana is also a regular guest speaker in the graduate PK/PD course at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences.

Certificate

By completing/passing this course, you will attain the certificate Certificate of Completion

1
Course Introduction
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(200-OD) Course Files
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Introduction to PK/PD Modeling
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Linear Regression
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Quiz 1 - Linear Regression
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Nonlinear Regression - Part 1
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Quiz 2a - Nonlinear Regression
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Nonlinear Regression - Part 2 - Historical Methods
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Quiz 2b - Nonlinear Regression
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Nonlinear Regression - Part 3 - MLE
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Quiz 2c - Nonlinear Regression
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Introduction to Phoenix Model Object
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Quiz 3 - Phoenix Model Object
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Residual Error Models - Part 1
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Quiz 4a - Residual Error Models
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Residual Error Models - Part 2
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Quiz 4b - Residual Error Models
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Model Output - Part 1
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Quiz 5a - Model Output
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Model Output - Part 2
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Quiz 5b - Model Output
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How to Obtain a Smooth Predicted Line
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Exercise 1 (PK1)
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Exercise 2 (PK52)
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Exercise 3 (PK18)
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Troubleshooting Phoenix
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Quiz 6 - Phoenix Model Object
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Comparing Models - Part 1
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Quiz 7a - Model Comparisons
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Comparing Models - Part 2
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Quiz 7b - Model Comparisons
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Comparing Models - Part 3
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Quiz 7b - Model Comparisons
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Assessment of Goodness of Fit
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Quiz 8 - GOF
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Exercise 4 (PK14)
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Exercise 5 (PK5)
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Exercise 6 (PK10)
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Introduction to Pharmacodynamics
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Quiz 9 - Intro to PD
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Direct PD Models - Part 1
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Quiz 10a - Direct PD Models
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PD Direct Models - Part 2
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Quiz 10b - Direct PD Models
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Direct PD Models - Part 3
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Quiz 10c - Direct PD Models
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Exercise 7 - PD30- Direct Models
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Temporal effects - Link Models - Part 1
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Quiz 11a - Temporal Effects
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Temporal effects - Link Models - Part 2
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Quiz 11b - Temporal Effects
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Indirect/Turnover Response Models - Part 1
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Quiz 12a - Indirect Models
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Indirect/Turnover Response Models - Part 2
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Quiz 12b - Indirect Models
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Indirect/Turnover Response Models - Part 3
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Quiz 12c - Indirect Models
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Indirect/Turnover Models - Part 4
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Quiz 12d - Indirect Models
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Exercise 8 (PD20)
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Exercise 9 (PD10m)
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Modeling Binary Outcomes - Part 1
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Quiz 13a - Binary Outcomes
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Modeling Binary Outcomes - Part 2
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Quiz 13b - Binary Outcomes
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Modeling Binary Outcomes - Part 3
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Quiz 13c - Binary Outcomes
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Modeling binary outcomes - Part 4
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Quiz 13d - Binary Outcomes
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Experimental Design - Part 1
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Quiz 14a - Experimental Design
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Experimental Design - Part 2
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Quiz 14b - Experimental Design
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Experimental Design - Part 3
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Quiz 14c - Experimental Design
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Experimental Design - Part 4
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Quiz 14d - Experimental Design
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Experimental Design - Part 5
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Quiz 14e - Experimental Design
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Experimental Design - Part 6
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Quiz 14f - Experimental Design
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Exercise 10 - Modeling and Simulation using a turnover Model
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Exercise 11 - SAD
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Combining Results - Part 1
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Quiz 15a - Combining results
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Combining Results - Part 2
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Quiz 15b - Combining results
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Combining Results - Part 3
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Quiz 15c - Combining results
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Combining Results - Part 4
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Quiz 15d - Combining results
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Exercise 12 - Remifentanil
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Course Recap
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Assistance
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Course Feedback
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