(300-OD) Advanced PK/PD Modeling using Phoenix WinNonlin

Content
36 modules

Difficulty
Advanced

Rating

Course Length
40 hours

Instructor
Thomas Jones

Price
$900 - 1800

Description

Cost - $1,800 (Academia $900)

This course aims to give the course participants confidence and encouragement to learn advanced topics in PK/PD data analysis, and to practice on real life case studies from discovery, preclinical and development. Lectures cover many topics including nonlinear absorption, nonlinear disposition, binary PD outcomes, experimental design, target mediated drug disposition, instantaneous and delayed drug responses, effect-compartment, turnover and binding models, modeling tolerance and rebound, transduction, and an introduction to population PK.

If you are an academic user, please contact us so we can update your account profile to give you access to academic pricing.  Note that you must register with an email address that is associated with an academic institution to get academic pricing.

Software Used

Phoenix WinNonlin™ and Phoenix NLME™

A temporary (30-day) license is provided to subscribers of this course.  When you are ready to start the practice exercises in this course, contact us to request your license.

Accessing the Course

After registering for this course, login to www.certarauniversity.com and you will see the course on your Dashboard.

You will have access to this course for a period of 3 years after the purchase.

The purchase is for a single seat in the course. No sharing the login between different individuals is allowed. Additional seats must be purchased if more than one person wishes to take the training course.

Course Length: 

The course provides approximately 10 hours of video instruction which includes a practical component that you can do at your own pace. It is expected to take participants about 40+ hours to complete, including time to perform the tasks in Phoenix.

Prerequisites

Participants need to have a good understanding of Phoenix WinNonlin and PML coding (for custom models).

Participants should also be able to perform the tasks in the following Certara University courses:

  • Intermediate PK/PD Modeling Using Phoenix WinNonlin (On-Demand 200-OD or Classroom 200-CL)

Instructor

Tom Jones

Tom Jones has helped thousands of scientists become proficient with using Certara software in their research in the pharmaceutical industry. After completing his Ph.D. in analytical chemistry, he spent several years as an assistant professor, during which time he applied molecular modeling to teaching and research in chemistry, and then came to Certara, where for 18 years he has applied his passion for teaching scientific software applications. At first Tom was focused exclusively on molecular modeling applications in drug discovery and later broadened his expertise to include informatics and PK/PD modeling and analysis. He has created many training manuals, and you may very well have heard his voice in one of the numerous webinars and video demos he has created to help scientists become more proficient with Certara software.

Dan Weiner

Dan Weiner has extensive drug development experience and has served as an expert consultant to the U.S. Food and Drug Administration (FDA) on pharmacokinetic modeling and bioequivalence assessment. Prior to his previous tenure with Certara/Pharsight as a Senior Vice President and Chief Science Officer, Dr. Weiner held several management positions with Merrell Dow Pharmaceuticals; Statistical Consultants, Inc.; Syntex Development Research; Quintiles; and IVAX Research. Dr. Weiner graduated from the University of Kentucky with a doctoral degree in Mathematical Statistics, with emphasis on compartmental modeling. He is the original designer/author of the WinNonlin family of PK/PD Modeling Software now used by over 1,000 institutions. He is the co-author of Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, now in its 5th ed. Dr. Weiner is an Adjunct Associate Professor with Division of Pharmacotherapy and Experimental Therapeutics in the School of Pharmacy, University of North Carolina and is an Affiliate Professor of Pharmacometrics, Center for Translational Medicine in the School of Pharmacy at the University of Maryland. During his career he has provided PK/PD training to over 2,000 students.  He is currently a consultant in model-based drug development.

Certificate

By completing/passing this course, you will attain the certificate Certificate of Completion

1
Course Introduction
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2
Course Files (Datasets and Solutions)
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3
Lecture: Nonlinear Absorption (3 parts)
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Quiz: Nonlinear Absorption
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Exercise PK3: Zero and First Order Absorption (3 parts)
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6
Exercise PK30: Subcutaneous Dosing of Hormone (4 parts)
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7
Exercise PK42: Nonlinear Absorption Models (3 parts)
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8
Lecture: Nonlinear Disposition (2 parts)
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Quiz: Nonlinear Disposition
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PK19 Exercise: Nonlinear Metabolite Kinetics (4 parts)
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Lecture: Classical PD Models for Direct Effects and Effect Compartment Models
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Quiz: PD Models
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PD22 Exercise: Effect Compartment Model (5 parts)
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14
Lecture: Modeling of Binary Outcomes (2 parts)
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Quiz: Modeling Binary Outcomes
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16
Exercise: Logistic Regression (3 parts)
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Lecture: Intro to Turnover/Indirect Response Models (2 parts)
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Quiz: Indirect Response Models
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Exercise PD4: Indirect Response Models (4 parts)
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Exercise PD38: Turnover Model with Repeated Dosing (2 parts)
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Lecture: Modeling Tolerance and Rebound
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Quiz: Tolerance and Rebound
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Exercise PD35: Transduction Models (4 parts)
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Lecture: Fate of mAbs and Target-Mediated Drug Disposition
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Quiz: Fate of mAbs and Target-Mediated Drug Disposition
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26
Exercise TMDD: Target Mediated Drug Disposition
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27
Lecture: Experimental Design (3 parts)
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Quiz: Experimental Design
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Lecture: Population Modeling 1 (3 parts)
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Quiz: Population Modeling 1
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Lecture: Population Modeling 2 (5 parts)
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Quiz: Population Modeling 2
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33
Exercise: Use of a Satellite PK Study to Generate Post-Hoc Estimates for a Sparsely Sampled PD Study (4 parts)
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34
Exercise on Population Modeling: Remifentanil (4 parts)
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35
Course Recap
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Course Feedback Survey
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Added 3 months ago, by Catalin
Thank you !!
 
Added 5 months ago, by Yoko
 
Added 7 months ago, by Dominique
Nice course, very complete, interesting for both the PK and PKPD theoretical aspects and a better use of Phoenix
 
Added 7 months ago, by Adarsh
 
Added 7 months ago, by Nanqun

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If you cannot attend the session for which you have enrolled, you can (1) choose a different session of the same course, (2) have another person attend in your place, or (3) you may be able to get a full or partial refund, based on the number of days prior to the session, as shown in the table.  

Notification of Cancellation by Participant Amount of Refund
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60 Calendar Days or More 100% Refund

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