(207-LO) 2021-11 Intermediate PK/PD Modeling using Phoenix WinNonlin and Phoenix NLME | November-December 2021

29 modules



Course Length
30 hours

Tom Jones

$250 - 500


Cost - $500 (Academia $250, India $125)

Course Description

The objective of this intermediate course is to consolidate knowledge of PK/PD concepts and advance to performing more complicated PK/PD modeling using Phoenix WinNonlin and Phoenix NLME.  You will learn how to customize your own models beyond library models, how to interpret and present your results, perform simulations, and how to deal with different types of covariates such as occasion covariates, and much more.  This course will also cover pharmacodynamic concepts and examples. Many case studies will be presented (please see agenda below). 

If you are an academic user, please contact us so we can update your account profile to give you access to academic pricing.  Note that you must register with an email address that is associated with an academic institution to get academic pricing.

If you are located in India, please contact us so we can provide a coupon that will give 75% off the full price of the course.  You will need to provide proof that you are physically located in India to get the coupon.

Course Format, Language and Dates

NEW: Starting in 2021, we offer 2 different office hours to provide Live support with this course around the globe.

This course format is as a ‘Live on-line classroom’ which means that the course is delivered virtually by an expert Phoenix instructor at pre-specified times.  This format provides the benefit of the classroom setting, with real-time interaction with the instructor but without the travel.  Although live attending is encouraged, recordings of the sessions are available to participants during the length of the course. 

This course will be delivered in English.

The course runs from the 9 of November to the 14 of December,  2021. This course will start on 9 November 2021 and will run for 6 sessions every Tuesday from 10am to 12pm EST (New York).  There are two options for office hours to help with assignments:

  • Option A: Fridays from 11am to 12pm EST (New York, GMT-5) 
  • Option B: Fridays from 2pm to 3pm (Brisbane, Australia, GMT+10)

Prerequisites and Time Commitment

Good knowledge of PK/PD concepts including compartmental models for both individual and population.  Experience with the functionality of Phoenix WinNonlin and Phoenix NLME software.  Prerequisite background courses or similar experience include:  [(123-LO) PK Modeling and Simulation and (124) Introduction to Population Modeling] or [(100-OD) Introduction to Phoenix WinNonlin and (101-OD) Introduction to Population Modeling]

Students are expected to be able to commit 5 hrs a week to attend sessions and complete assignments.


Phoenix WinNonlin and Phoenix NLME

Participants are expected to have a current license to Phoenix WinNonlin and Phoenix NLME.  If a 60-day software license is needed one can be provided for an additional fee.  Contact us if you want to order a license.

Certara Professional Certification [Optional]

Participants may opt to pay a fee ($50) to obtain an additional professional certification as a Level 1 Pharmacometrician.  This certification requires passing an exam that this course will give you the sufficient knowledge to pass.  Contact us to add this certification to this course registration.  Click here for more details on Certara Professional Certifications.


Agenda for the Live Online Course 207-LO

Intermediate PK/PD Modeling using Phoenix WinNonlin and Phoenix NLME





  • Course Logistics

  • Review of Phoenix Library models and output

  • Graphical Model Building

  • Customizing models

  • Pharmacometrics Modeling Language (PML)



PK Case Studies:

  • TMDD examples

  • Enterohepatic Recycling

  • Transit Compartment (transit PML statement)

  • Models with Delays (Delay statement + GammaDelay)


  • Understanding Advanced Run Options

    1. NP-MAP

    2. How to obtain Standard Errors

    3. ODEs Solvers, etc.

  • Reporting model results

  • Translating published models to Phoenix NLME



  • Covariate Structure

  • Continuous

  • Categorical

  • Occasion

  • The QRPEM engine


  • Pharmacodynamics

    • Emax Models

    • Delay Response Models

    • Binary response Models

  • Simulation


  • More on Model Validation techniques (e.g. VPC)

  • Posthoc estimates without fitting the model

  • Introductory demo to RsNLME

  • Next Steps

  • Adjourn



By completing/passing this course, you will attain the certificate Certificate of Completion

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