(207-LIVE) Intermediate PK/PD Modeling using Phoenix WinNonlin and Phoenix NLME | November - December 2024

Content
17 modules

Difficulty
Intermediate

Rating

Course Length
30 hours

Instructor
Tom Jones

Price
$125 - 500

Description

November - December 2024


Cost - $500 (Academia $250, India $125)


Course Description

The objective of this intermediate course is to consolidate knowledge of PK/PD concepts and advance to performing more complicated PK/PD modeling using Phoenix WinNonlin and Phoenix NLME.  You will learn how to customize your own models beyond library models, how to interpret and present your results, perform simulations, and how to deal with different types of covariates such as occasion covariates, and much more.  This course will also cover pharmacodynamic concepts and examples. Many case studies will be presented (please see agenda below). 

If you are an academic user, please contact us so we can update your account profile to give you access to academic pricing.  Note that you must register with an email address that is associated with an academic institution to get academic pricing.

If you are located in India, please contact us so we can provide a coupon that will give 75% off the full price of the course.  You will need to provide proof that you are physically located in India to get the coupon.

Course Format, Language and Dates

This course format is as a ‘Live on-line classroom’ which means that the course is delivered virtually by an expert Phoenix instructor at pre-specified times.  This format provides the benefit of the classroom setting, with real-time interaction with the instructor but without the travel.  Although live attending is encouraged, recordings of the sessions are available to participants during the length of the course. You will have access to the recordings for 3 months following the last session of the course.

This course will be delivered in English.

This course will be offered in November and December 2024.  There will be six two-hour lecture/demo sessions.  Lecture/Demo sessions are on Tuesdays at 10 AM New York (GMT-4), starting 5 November and finishing 17 December.  We will record sessions and post the recordings for those who are unable to attend live.

There are also five weekly office hour sessions, in which gives a more extended period for asking and answering questions.  We have two options for people in different time zones: 

  • Office Hour Option A is offered at times most convenient for participants in the Americas, Europe, and Africa.  They are on Fridays at 11 AM New York (GMT-4). 
  • Office Hour Option B is offered at times most convenient for participants in Asia/Pacific.  They are on Tuesdays at 2 PM Brisbane (GMT+10).  (FYI, 2 PM Tuesday in Brisbane is late Monday evening in New York.)

Prerequisites and Time Commitment

Good knowledge of PK/PD concepts including compartmental models for both individual and population.  Experience with the functionality of Phoenix WinNonlin and Phoenix NLME software.  Prerequisite background courses or similar experience include:  [(123-LO) PK Modeling and Simulation and (124-LO) Introduction to Population Modeling] or [(100-OD) Introduction to Phoenix WinNonlin and (101-OD) Introduction to Population Modeling]

Students are expected to be able to commit 5 hrs a week to attend sessions and complete assignments.

Software

Phoenix WinNonlin and Phoenix NLME

Participants are expected to have a current license to Phoenix WinNonlin and Phoenix NLME.  If a 60-day software license is needed one can be provided for an additional fee.  Contact us if you want to order a license.

Certara Professional Certification [Optional]

Participants may opt to pay a fee ($50) to obtain an additional professional certification as a Level 1 Pharmacometrician.  This certification requires passing an exam that this course will give you the sufficient knowledge to pass.  Contact us to add this certification to this course registration.  Click here for more details on Certara Professional Certifications.

Objectives

Agenda for the Live Online Course 207-LO

Intermediate PK/PD Modeling using Phoenix WinNonlin and Phoenix NLME

 

Session

Topics

1

  • Course Logistics

  • Review of Phoenix Library models and output

  • Graphical Model Building

  • Customizing models

  • Pharmacometrics Modeling Language (PML)

 

2

PK Case Studies:

  • TMDD examples

  • Enterohepatic Recycling

  • Transit Compartment (transit PML statement)

  • Models with Delays (Delay statement + GammaDelay)

3

  • Understanding Advanced Run Options

    1. NP-MAP

    2. How to obtain Standard Errors

    3. ODEs Solvers, etc.

  • Reporting model results

  • Translating published models to Phoenix NLME

 

4

  • Covariate Structure

  • Continuous

  • Categorical

  • Occasion

  • The QRPEM engine

5

  • Pharmacodynamics

    • Emax Models

    • Delay Response Models

    • Binary response Models

  • Simulation

6

  • More on Model Validation techniques (e.g. VPC)

  • Posthoc estimates without fitting the model

  • Introductory demo to RsNLME

  • Next Steps

  • Adjourn

 

Certificate

By completing/passing this course, you will attain the certificate Certificate of Completion

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FAQ for Certara University Live Online Courses
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Office Hours Survey
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207-LO Zoom Sessions (2024-11)
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Week 1
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Assignment 1
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Week 2
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Assignment 2
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Bonus Recording: Introduction to Population Modeling
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Week 3
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Assignment 3
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Week 4
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Assignment 4
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Week 5
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Assignment 5
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Week 6
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Bonus Recording: How to fix Phoenix Display Issues
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End of Course Survey
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